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Studies have shown that it increases the risk of events such as stroke, heart attack and pulmonary edema. One theory suggests that the drug thickens the blood to the point where it produces fatal clots. Such complications may have contributed to the deaths of at least 20 cyclists by 2000, increasing the urgency to develop a reliable test to detect EPO [source: Zorpette]. In 2007, anti-doping agencies introduced the concept of a “biological passport,” a record of the substances found normally in an athlete’s blood and urine, created by repeated sampling over time. By comparing the results of a blood test administered right before a competition to the passport, officials can determine if an athlete has been using EPO or other performance-enhancing drugs. Like EPO, human growth hormone ( hGH ) occurs naturally in the body, buy santra 1 mg antiestrogens arimidex. In fact, the pituitary gland, the pea-sized organ located at the base of the brain, produces hGH to stimulate growth in children and adolescents and to increase muscle mass in adults. As soon as synthetic hGH became available as a prescription medication in 1985, when the U. Food and Drug Administration approved its use for a number of diseases that retard growth or cause muscle deterioration, athletes began eyeing it as a doping agent. They figured it could mimic the muscle-building effects of anabolic steroids. At first, the high cost of the medication discouraged widespread use as a PED, but, as the saying goes, where there’s a will to win, there’s a way. The 1996 Olympic Games have been called the “hGH Games” because of the rampant use of the drug among competitors. Today, athletes get hGH from a variety of sources: doctors who are willing to write prescriptions for off-label use, Internet pharmacies, illicit Web sites for performance-enhancing drugs and clinics that use the hormone to reverse the effects of aging. A few even turn to black-market dealers that collect hGH from human cadavers. It’s a risky gamble, especially considering the lack of scientific evidence to suggest that hGH actually increases athletic performance. Oh, and don’t forget the side effects. Using hGH has been linked to a variety of medical conditions, including joint pain, muscle weakness, fluid retention, carpal tunnel syndrome, cardiomyopathy and hyperlipidemia [source: Mayo Clinic]. Another performance-enhancing drug that made the 1996 Olympic Games memorable for the wrong reason was bromantan , a sort of stimulant and masking agent combined in one. Several Russians tested positive for the drug, which was not, at the time, included on the International Olympic Committee’s (IOC’s) list of banned substances. That didn’t stop the IOC from disqualifying several Russian athletes, stripping medals from two and, ultimately, blacklisting bromantan based on its performance-enhancing effects. Those effects are quite unlike any other PED. Russian army doctors developed bromantan as a stimulant, something they could give to soldiers and cosmonauts to help them feel more alert and fight fatigue. Soon after, Russian athletes got hold of the drug, reporting that it helped them perform at peak levels without feeling exhausted. But the story appears more complicated. Some anti-doping officials believe bromantan can hide the abuse of more serious drugs, such as steroids.
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