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Sporting performance among their female athletes, particularly in strength-dependent events, was spectacular. Following the reunification of Germany in 1990, ground-breaking documental research was made by the former athlete, Mrs Brigitte Berendonk, and her husband Professor Werner Franke, who had succeeded in acquiring a number of highly classified scientific reports that had not been destroyed. These documents deal with the systematic state-sponsored programme of doping of athletes and included scientific reports, doctoral theses and a hand-written protocol book giving the times and dosage of administration of anabolic steroids to athletes. Several thousand athletes were treated with anabolic steroids every year, including adolescents of each sex. Particular emphasis was placed on the administration of anabolic steroids to women and adolescent girls, despite the virilizing effects, because of the rapid gains in sporting performance. It is important to note that the GDR scientists established (to themselves) that ‘androgenic initiation’ has permanent effects in girls and women, where increases in strength and performance do not return to pretreatment values after the drug is withdrawn. The current emphasis on out-of-competition drug testing is, therefore, of vital importance to help prevent doping during training followed by a period of drug elimination and then competition. With respect to men, a most comprehensive review in 1976 of previous results concluded that there was little evidence for supraphysiological doses of testosterone or synthetic anabolic steroids having any appreciable effect on muscle size or strength in healthy men (Ryan, 1976). Even so, many of the studies reviewed had a lack of adequate control and standardization. Despite the debate in the scientific community as to the effectiveness of anabolic steroids as performance enhancers in men, male athletes and bodybuilders continued to use them, knowing from their own experimentation that they were effective. Conclusions from more recent reviews suggested that the administration of anabolic steroids could consistently result in significant increases in strength if male athletes satisfied certain criteria including the timing of doses and dietary factors (Wright, 1980; Haupt and Rovere, 1984; Alen and Hakkinen, 1987; Strauss and Yesalis, 1991). Then in 1996, Bhasin et al. Subsequent work showed that increases in fat-free mass, muscle size, strength and power are highly dose-dependent and correlated with serum testosterone concentrations (Bhasin et al. Several track and field events demand explosive power, which depends on athletes first developing a solid strength base). The implications of these subsequent findings need to be emphasized to those concerned with antidoping in sport, in that an approximate doubling of the serum total and free concentrations of testosterone from the baseline values in eugonadal men over a 20-week period caused significant increases in strength and power (see the results reported by Bhasin et al. Although the serum testosterone was measured 7 days after previous injection, which reflect the lowest values after administration, such androgen exposure is relatively small in the context of the regimens often written about in connection with bodybuilding. Even with respect to athletes, this dose is small compared with the amounts that some athletes may have been administering around 30 years ago, as Wright (1980) comments during that period that ‘it is not uncommon for the dose level in national calibre athletes to exceed 1 mg/kg of body weight per day with a rather large number of individuals using two to four times that quantity. The use of smaller doses of anabolic steroids, particularly those formulated for daily administration (such as transdermal applications of testosterone as opposed to i. Out-of-competition testing should counter this strategy. Regardless of the above, it should be stressed that due to anabolic steroid administration being covert in athletics for obvious reasons, very little recent information has come to light regarding the doses of anabolic steroids used by elite athletes who choose to cheat. The undesirable effects arising from anabolic steroid administration ( Table 3 ) have been extensively reviewed (Haupt and Rovere, 1984; Di Pasquale, 1990; Graham and Kennedy, 1990; Landry and Primos, 1990; Shahidi, 2001; Kicman and Gower, 2003b; James and Kicman, 2004). Typically, anabolic steroids are taken in cycles of about 6’12 weeks (the ‘on period’) followed by a variable period off the drugs, from 4 weeks to several months (the ‘off period’) in an attempt to reduce the likelihood of undesirable effects but some bodybuilders will take them almost continuously, best online steroid sites australia. Adverse effects from anabolic steroid administration. Target Adverse effect Comment Bone Premature closure of the epiphysis in children Stunting of linear growth Breast Atrophy in women Gynaecomastia and enlarged nipples in men Gynaecomastia can be pronounced and painful; corrective surgery may be necessary. As some anabolics are known to be resistant to aromatization, other mechanisms need to be considered, such altered hepatic function causing an imbalance between androgens and estrogens Cardiovascular Increases risk of thrombotic events such as myocardial infarction or stroke (raised LDL, lowered HDL and apolipoprotein-1, raised haematocrit (due to polycythaemia) and lowered plasma fibrinogen Cardiac damage (left ventricular hypertrophy, fibrosis and heart failure) Sudden cardiac death The link between long-term anabolic steroid use and cardiovascular events remains to be clearly established but the evidence gathered is fairly compelling.
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