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Between 3 and 5 in 10 people who take steroid medicines in the long term will develop a fragility fracture because of osteoporosis if nothing is done to prevent this.
Statin medicines which prevent osteoporosis
In the past few years, a new class of medicines (diethylstilbestrol) and a new type of hormone have been introduced, which seem to prevent the risk of fragility fractures caused by increased bone density, but this is still not yet clear with regards to overall survival.
There are two types of the steroid drug which are used for osteoporosis treatment, the first is called androgenic-only treatments; and the second is a drug which also has estrogenic activity and works as a combination in androgen-treated people. When the drug is taken together with an estrogen-containing contraceptive, the effect of the drug to prevent fragility fractures will be reduced (1, 2).
Stratocumulative steroid hormones.
The first of the new drugs to be recommended as long term medicine for women is a drug called norgestrel. This will cause the body to hold onto oestrogen, which could prevent it being used to make estrogenic oestrogen. So a women on this drug should not take contraceptive pills (3).
Stratocumulative steroids can reduce bone loss over time when compared to the other new drugs used for osteoporosis. If the same dose of the steroid drug administered for four years is given over four years, this drug will result in significantly reduced bone loss compared to the other steroid drugs available (4, 5, 6, 7).
As there have so far only been two studies on the effects of norgestrel on bone mineral density and women’s bone strength, this drug is still not available for women.
Another new drug, the progestin-only estrogen, has also been introduced and is given in combination with the steroid-containing drug.
This new pill has been shown to reduce bone loss from all causes of bone loss – osteoporosis and fractures (8). However, more studies are needed in order to find out what the effects are of taking progestin-only estrogen on bone health (9). The progestin-only estrogen pill could also reduce the risk of fragility fractures in women when compared to the current drug therapies (10). The pill is currently being studied in women aged between 20 and 40 who are taking oral contraceptives, but there is no evidence at present that the pill is effective for women taking oral contraceptives alone (11).
The progestin-only estrogen pill can be
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